Heterogeneous electrical memory in restitution of action potential duration in pig ventricles
نویسندگان
چکیده
منابع مشابه
Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles.
BACKGROUND Apamin-sensitive K currents (I(KAS)) are upregulated in heart failure. We hypothesize that apamin can flatten action potential duration restitution (APDR) curve and can reduce ventricular fibrillation duration in failing ventricles. METHODS AND RESULTS We simultaneously mapped membrane potential and intracellular Ca (Ca(i)) in 7 rabbit hearts with pacing-induced heart failure and i...
متن کاملHuman ventricular action potential duration restitution.
. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391–6. . Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 1999;100:1660–6. . Breithardt G, Cain ME, El-Sheri...
متن کاملAction potential duration restitution kinetics in human atrial fibrillation.
OBJECTIVES We undertook this study to determine whether human atrial fibrillation (AF) relates to steeply sloped action potential duration restitution (APDR) kinetics and whether the spatial nonuniformity of APDR promotes persistence of AF. BACKGROUND A steeply sloped APDR curve is known to be an important determinant of the induction of more complex action potential duration (APD) dynamics a...
متن کاملDynamic restitution of action potential duration during electrical alternans and ventricular fibrillation.
The restitution kinetics of action potential duration (APD) were investigated in paced canine Purkinje fibers (P; n = 9) and endocardial muscle (M; n = 9), in isolated, perfused canine left ventricles during ventricular fibrillation (VF; n = 4), and in endocardial muscle paced at VF cycle lengths (simulated VF; n = 4). Restitution was assessed with the use of two protocols: delivery of a single...
متن کاملEffects of Calcium Changes on Hysteresis in Restitution of Action Potential Duration
OF THESIS EFFECTS OF CALCIUM CHANGES ON HYSTERESIS IN RESTITUTION OF ACTION POTENTIAL DURATION Sudden cardiac death (SCD) is a leading cause of fatalities. Several methods have been developed to predict instability in myocytes which could lead to SCD. The focus of this study was on altering memory in myocytes, i.e. hysteresis in restitution of action potential duration (APD), by differing level...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.781.1